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How Semaglutide and Tirzepatide Support Weight Loss in Women with PCOS
- Dr Titilayo Akinsola
- Sep 18
- 3 min read
Updated: Sep 30
Polycystic Ovary Syndrome (PCOS) affects nearly 1 in 10 women of reproductive age, often bringing a frustrating mix of symptoms: irregular cycles, infertility, acne, and stubborn weight gain that won’t budge no matter how hard you diet or exercise.
Much of this difficulty comes from insulin resistance, a common feature of PCOS. That’s where breakthrough medications like semaglutide (Ozempic®, Wegovy®) and tirzepatide (Mounjaro®) are showing promise. Originally developed for type 2 diabetes, these treatments are now being used to help women with PCOS lose weight and improve their overall metabolic health.
At Favor Mental Health in Bel Air, MD, we see firsthand how these medications can be life-changing for women who feel stuck in a cycle of fatigue, weight struggles, and hormonal imbalance.
Why Weight Loss Is So Challenging with PCOS
PCOS disrupts how the body processes insulin. This makes it easier to store fat and harder to burn it off, even with strict diet and exercise. As a result:
Women may experience unexplained weight gain or difficulty losing weight.
Weight struggles often worsen irregular cycles and fertility issues.
Insulin resistance increases the risk of type 2 diabetes, high cholesterol, and heart disease.
Traditional advice like “eat less, exercise more” often doesn’t work for women with PCOS — because the problem is hormonal, not just behavioral.
How Semaglutide and Tirzepatide Can Help
These medications target the root metabolic issues linked to PCOS:
Semaglutide (GLP-1 agonist): Slows digestion, reduces appetite, and improves insulin sensitivity.
Tirzepatide (GLP-1 + GIP agonist): Provides dual action for potentially greater weight loss and blood sugar control.
Benefits for women with PCOS include:
Significant weight loss, often 10–20% of body weight.
Improved insulin resistance, making it easier to regulate hormones.
Better menstrual cycle regularity, which may support fertility.
Reduced risk of long-term complications like diabetes and cardiovascular disease.
Safety and Considerations
While promising, these medications aren’t for everyone. Women with certain thyroid conditions, pancreatitis, or specific medical histories may not be candidates. Common side effects can include:
Nausea
Constipation
Abdominal discomfort
That’s why close monitoring and a personalized treatment plan are essential.
The Favor Mental Health Approach
We don’t believe in one-size-fits-all care. When helping women with PCOS, we:
Conduct a comprehensive medical evaluation, including hormone and metabolic testing.
Assess whether semaglutide or tirzepatide is safe and appropriate.
Create a customized plan that integrates medication, nutrition guidance, and follow-up care.
Monitor both physical and emotional health, since PCOS often impacts mental wellbeing as well.
A Patient Story from Bel Air
One 32-year-old woman with PCOS came to us after years of trying diets, exercise programs, and even fertility treatments without success. After starting semaglutide under medical supervision, she lost 35 pounds in one year, her cycles became more regular, and her energy improved dramatically.
She told us: “I finally feel like my body is working with me instead of against me.”
Reclaim Control Over PCOS and Weight
If PCOS has made weight loss feel impossible, know that new solutions exist. Medications like semaglutide and tirzepatide may provide the breakthrough you need — not just for weight, but for hormones, fertility, and long-term health.
Visit our website today to schedule your confidential consultation and explore if these treatments are right for you.
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