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Tirzepatide vs Semaglutide: Comparing Side Effects Before Choosing a Weight Loss Medication
- Dr Titilayo Akinsola
- Oct 1
- 3 min read
Medications like Tirzepatide (Mounjaro®, Zepbound®) and Semaglutide (Ozempic®, Wegovy®) are changing the way people approach weight management. For many patients in Bel Air, Maryland, these treatments offer a new path forward when diet and exercise alone have not worked.
But as powerful as these medications are, they come with side effects that every patient should understand before starting treatment. At Favor Mental Health, we believe that informed choices—backed by professional support—are the foundation of safe and successful weight loss.
How These Medications Work (And Why Side Effects Happen)
Semaglutide works by mimicking GLP-1, a hormone that slows digestion and reduces appetite.
Tirzepatide works on both GLP-1 and GIP receptors, creating stronger effects on weight and blood sugar control.
Because both drugs slow the digestive process, the most common side effects occur in the gastrointestinal (GI) system. These typically appear when starting treatment or increasing the dose.
Side Effect Comparison: Tirzepatide vs Semaglutide
Side Effect | Semaglutide | Tirzepatide |
Nausea & Vomiting | Very common during dose increases; usually lessens over time. | Also very common; can be more intense during early titration. |
Diarrhea | Frequently reported, especially at higher doses. | Common, often accompanied by bloating or abdominal discomfort. |
Constipation | More common with Semaglutide; can persist. | Less frequent than with Semaglutide but still possible. |
Abdominal Pain / Bloating | Present, especially in early weeks. | Often slightly more pronounced in early phases. |
Fatigue / Dizziness | Reported but less common. | Reported slightly more often than with Semaglutide. |
Injection Site Reactions | Mild redness, itching, or swelling in some patients. | Similar reactions, sometimes reported more frequently. |
Serious Risks (rare) | Pancreatitis, gallbladder disease, thyroid C-cell tumors (animal studies), dehydration from vomiting/diarrhea. | Similar risks as Semaglutide, with slightly higher discontinuation rates at very high doses. |
What Clinical Trials Show
In the SURPASS-2 trial, patients on Tirzepatide reported more gastrointestinal side effects than those on Semaglutide 1 mg, but most were mild to moderate and improved over time.
In head-to-head comparisons, both drugs caused temporary GI symptoms during dose escalation, with Tirzepatide causing more intense side effects at higher doses.
Importantly, discontinuation rates (patients stopping treatment due to side effects) were slightly higher with Tirzepatide, but not dramatically so.
What Patients Can Expect
Side effects usually improve
The first 4–8 weeks are often the toughest. Once the body adjusts, most patients tolerate the medication well.
Dose titration is key
Both medications require starting at a low dose and gradually increasing. This minimizes nausea, vomiting, and diarrhea.
Simple lifestyle adjustments help
Eating smaller, lighter meals, avoiding greasy foods, and staying hydrated can significantly reduce side effects.
Individual response varies
Some patients tolerate Semaglutide better, while others do well on Tirzepatide despite stronger early side effects.
Choosing the Right Medication in Bel Air, MD
At Favor Mental Health, we understand that choosing between Tirzepatide and Semaglutide isn’t just about the number on the scale, it’s about:
Your medical history (digestive issues, thyroid health, diabetes status)
Your lifestyle (ability to handle GI adjustments, motivation for weight loss)
Your mental health (coping with body image, food anxiety, or frustration from side effects)
Your insurance & access (coverage and affordability can differ)
Our team provides:
✔️ Comprehensive medical evaluation before prescribing
✔️ Tailored titration plans to minimize side effects
✔️ Ongoing support for both physical and mental health during your weight loss journey
✔️ Confidential, compassionate care right here in Bel Air
Bottom Line
Both Tirzepatide and Semaglutide are effective tools for weight loss, but side effects are part of the journey. The good news is that, with proper guidance, most side effects are temporary, manageable, and worth the results patients achieve.
If you’re ready to explore your options for weight loss medication in Bel Air, Maryland, Favor Mental Health is here to help you do it safely and with the support you deserve.
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